FRIDAY, January 27, 2012 -- The U.S. Food and Drug Administration today approved Inlyta (axitinib) to treat patients with advanced kidney cancer (renal cell carcinoma) who have not responded to another drug for this type of cancer. Renal cell... (Source: Drugs.com - New Drug Approvals)

The US FDA has approved Inlyta (axitinib) for the treatment of advanced renal cell carcinoma, a type of kidney cancer, in patients with whom other drugs have not been effective, the FDA (Food and Drug Administration) announced today. Inlyta is made and marketed by pharmaceutical giant Pfizer Inc. Renal cell carcinoma - also known as renal cell cancer or hypernephroma, is a type of kidney cancer that starts in the lining of the tiny renal tubes (proximal convoluted tubule). These tubes filter the blood and produce urine. This type represents 80% of all kidney cancers... (Source: Health News from Medical News Today)

A recent study that took place at the Centre for Brain and Cognitive Development, Birkbeck, University of London, and was published in the January edition of Current Biology, states that detecting autism symptoms in babies as young as 6 months old can help to determine how the autism will develop later in the child's life. The researches found that babies show signs of autism in their first year of life. When the babies are looked at, or when someone looks away from them, their brain responds differently compared to other babies... (Source: Health News from Medical News Today)

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WASHINGTON (Reuters) - Pfizer's Inlyta drug for patients with advanced kidney cancer won approval from U.S. regulators, boosting the company's efforts to offset plunging Lipitor sales. (Source: Reuters: Health)

This study traced MSCs participating in wound healing by using small intestinal submucosa (SIS) as a cell carrier, identified their moving path and calculated the number of MSCs involved in wound healing. First, MSCs were isolated from the nude mouse and 1 × 106 cells were seeded onto the centre of the SIS. MSC‐seeded SIS complexes were injected onto full‐thickness skin wounds made on the dorsum of nude mice. Tracing of MSC‐seeded SIS complex transplanted to the wound site revealed that 27.6% of the MSCs were migrated to the wound site at the first attempt. Second, repeated injection of additional MSCs did not increase the number of MSCs participating in wound healing beyond a certain constant maximum amount. The number of MSCs present in the wound site remains constant in the r...

Org. Biomol. Chem., 2012, Advance ArticleDOI: 10.1039/C2OB06648C, PaperAngel Martinez-Castaneda, Humberto Rodriguez-Solla, Carmen Concellon, Vicente del AmoThe catalytic system TBD/Al2O3 allows the preparation of thermodynamically-controlled pools of aldols, interconverting through an aldol/retro-aldol sequence, from which moderate levels of diastereoselectivity can emerge.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic Biomolecular Chemistry)

Org. Biomol. Chem., 2012, Accepted ManuscriptDOI: 10.1039/C2OB07004A, CommunicationYongzhou Hu, Xin Li, Shufang HuangRegioselectively brominated BODIPYs were shown to undergo nucleophilic substitution and Sonogashira coupling reactions with a one-pot procedure, yielding diversely substituted fluorophores.The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic Biomolecular Chemistry)

Org. Biomol. Chem., 2012, Accepted ManuscriptDOI: 10.1039/C2OB07079K, PaperShiya Tang, Jing Shi, Qingxiang GuoBioorthorgonal reactions are useful tools to gain insights into the structure, dynamics, and function of biomolecules in the field of chemical biology. Recently, Diels-Alder reaction is a promising and attractive...The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic Biomolecular Chemistry)

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Org. Biomol. Chem., 2012, Advance ArticleDOI: 10.1039/C2OB06434K, PaperZhi-Ming Zhou, Zhi-Huai Li, Xiao-Yan Hao, Jun Zhang, Xiao Dong, Ying-Qiang Liu, Wen-Wen Sun, Dan Cao, Jin-Liang WangC 2 -symmetric imidazolium-tagged bis(oxazoline) ligands were prepared, with an ee of up to 94%, and the catalyst could be reused 6 times without loss of activity/enantioselectivity.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic Biomolecular Chemistry)

Org. Biomol. Chem., 2012, Advance ArticleDOI: 10.1039/C2OB06938E, PerspectiveJean-Louis Reymond, Tamis DarbrePeptide dendrimers were selected from combinatorial libraries as esterase and aldolase models, drug delivery and antimicrobial agents, ligands for lectins, metals and vitamin B12.To cite this article before page numbers are assigned, use the DOI form of citation above.The content of this RSS Feed (c) The Royal Society of Chemistry (Source: RSC - Organic Biomolecular Chemistry)

WASHINGTON (MedPage Today) -- The delay is over for the diabetes drug Bydureon (exenatide extended-release), with FDA approval making it the first once-weekly treatment for type 2 disease. (Source: MedPage Today Public Health)

Cephalon, Inc. is voluntarily recalling Treanda® (bendamustine HCL) for Injection 25mg/8mL; lot TB30111, expiration date 12/2012. This product lot is being recalled due to the presence of particulate matter found in a single vial, which has been identified as glass fragments (Source: Food and Drug Administration)

The U.S. Food and Drug Administration said on Friday it had detained shipments of orange juice and concentrate from Brazil and Canada after finding traces of the unapproved fungicide carbendazim. (Source: WDSU.com - Health)

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The U.S. Food and Drug Administration said on Friday it had detained shipments of orange juice and concentrate from Brazil and Canada after finding traces of the unapproved fungicide carbendazim. (Source: CNN.com - Health)

In Colorado, a proposal to legalize possession of marijuana in small amounts is likely to be on the ballot this fall, backed by the Campaign to Regulate Marijuana Like Alcohol. (Source: NYT)

Alkermes Inc. (Nasdaq: ALKS) and its California partner Amylin Pharmaceuticals Inc. (Nasdaq: AMLN) have finally won approval from the FDA for the diabetes drug Bydureon after years of attempts. In a letter from the U.S. Food and Drug Administration’s Office of Drug Evaluation, the two partners were told that the New Drug Application that had been originally been submitted in May 2009 was approved and the contents of package labels should be sent to the office as soon as possible. Following the original application in 2009, the FDA issued a complete response letter in March 2010, requesting additional data before the potential drug could be approved... (Source: bizjournals.com Health Care:Biotechnology headlines)

Pharmaceutical manufacturer Perrigo Co. filed a WARN notice with the state about its intention to lay off 175 employees in Lake Worth. The Allegan, Mich.-based company (NASDAQ: PRG) said it would release the employees at 201 4th Avenue, North from April 1 through June 30. It entered that location in 2008 when it acquired Unico Holdings for $49 million. On Jan. 12, a West Palm Beach warehouse building that recently counted Unico/Perrigo as its largest tenant was hit with a $4.5 million foreclosure lawsuit... (Source: bizjournals.com Health Care:Biotechnology headlines)

AbstractOur approach was to synthesize and examine the antioxidant properties of some new 2‐[2‐(4‐chlorophenyl)benzimidazole‐1‐yl]‐N‐(2‐arylmethyleneamino) acetamide (1‐18) and 2‐[2‐(4‐chlorophenyl)benzimidazole‐1‐yl]‐N‐(4‐oxo‐2‐aryl‐thiazolidine‐3‐yl)acetamide (1t‐18t) derivatives. Their in vitro effects on rat liver microsomal NADPH‐dependent lipid peroxidation levels (LP assay) and microsomal ethoxyresorufin O‐deethylase activities (EROD assay) were determined. The free radical scavenging properties of the compounds were also examined in vitro determining the interaction of 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) free radical. The compounds showed significant effects in the above tests.© 2012 John Wiley & Sons A/S (Source: Chemic...

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WASHINGTON (Reuters) - Pfizer's Inlyta drug for patients with advanced kidney cancer got the nod from U.S. regulators on Friday, boosting the company's plans to offset plunging Lipitor sales. (Source: Reuters: Health)

AbstractSingle primer amplification is shown to yield a DNA profile that is reproducible when based on the sequence content of the amplicons rather than on the pattern of length polymorphism. The sequence‐based profile increases in reliability with increasing numbers of cycles of amplification. This process uses an arbitrarily chosen primer and a low initial annealing temperature in order to amplify sequences from the whole metagenome present in a sample that may contain only trace DNA, and a large number of cycles to select subsets of sequences based on variable amplification efficiency. Using arrays, we demonstrate the utility and limitations of this approach for profiling the large metagenomes typical of soils and the trace DNA present in drug seizures. We suggest that this type of pr...